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KMID : 1037020140030020065
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Medical Lasers; Engineering, Basic Research, and Clinical Application
2014 Volume.3 No. 2 p.65 ~ p.70
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Transmeatal Low Level Laser Therapy (LLLT) on Vestibular Inner Ear after Topical Gentamicin Ototoxicity
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Rhee Chung-Ku
Chang So-Young
Chung Phil-Sang
Ahn Jin-Chul
Jung Jae-Yun
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Abstract
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Background and Objectives: The objectives of this study is to evaluate any adverse effects on outer and inner ear structures after transmeatal low level laser therapy (LLLT) and to see the effects of transmeatal LLLT on gentamicin induced unilateral vestibulopathy in guinea pigs.
Materials and Methods: We measured penetration rate of transmeatal low level laser (LLL) into the perilymphatic space of cochlea through a tympanic membrane, cochlea wall and hearing level post transmeatal LLLT were measured. Histopathologic studies on ear canal skin and ear drum were performed for observation of any damage by LLLT. Guinea pigs were then divided into control and LLLT group. Both groups received injection of gentamicin (GM) into the left middle ear. LLLT group were irradiated into the left ear through the external ear canal for 5 days starting 1 day after GM injection into the left ear. The animals underwent sinusoidal oscillation about a vertical and off vertical axis 5 days post GM injection.
Results: No damage on ear canal skin and ear drum was noted and hearing remained normal after LLLT. The penetration rate of LLL through the drum was 8% and 5% of LLL penetrated into the perilymphatic space. The left side gains of the control group were significantly decreased compared to the left side gain of the LLLT group. The gains of the right ear in both groups were not significantly different.
Conclusion: This study demonstrated that transmeatal LLLT restores vestibular function in guinea pigs with gentamicin induced ototoxic dysfunction. LLLT may have clinical implications in the treatment of various vestibular diseases with vestibular dysfunction.
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KEYWORD
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LLT, Gentamicin, Ototoxicity, SHA, Vestibular dysfunction
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